|
KMID : 1177720170110010011
|
|
Journal of Alternatives to Animal Experiments
2017 Volume.11 No. 1 p.11 ~ p.18
|
|
|
Comparison of Reconstructed Human Skin Models with Human and Pig Skin in in-vitro Percutaneous Absorption
|
|
Han Ju-Hee
Kim C-Yoon
Lim Chae-Hyung
Na Yi-Rang
Kim Tae-Hyun
Jung Hyun
Seok Seung-Hyeok
Jung Cho-Rok
Park Jae-Hak
|
|
|
Abstract
|
|
|
|
This study was carried out in accordance with OECD guidelines on skin absorption test for the comparison of reconstructed human skin models, EFT-306™ and KeraSkinFT™ with human skin and pig skin. Three OECD standard compounds were used for penetration and absorption: Caffeine, benzoic acid and testosterone, all of which differ vastly in their lipophilicity. Reconstructed human skins were more permeable to low lipophilic compounds such as caffeine than human and pig skin. Differences became most obvious with KeraSkinFT™ showing a relatively weak penetration barrier on caffeine. EFT-306™ and KeraSkinFT™ both showed similar penetration patterns in the case of lipophilic compounds, benzoic acid and testosterone compared with human and pig skins. High correlation was observed on the penetration flux between the reconstructed human skin models and human and pig skin, even though different penetration rates existed. The reconstructed human skin models can be regarded as generally useful on lipophilic compounds for in-vitro penetration studies.
|
|
|
KEYWORD
|
|
|
In vitro skin absorption, human skin, pig skin, reconstructed human skin model
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|